What is Ipamorelin?

Ipamorelin is a synthetic pentapeptide that acts as a selective growth hormone secretagogue (GHS) and ghrelin mimetic. It binds to the GHSR-1a receptor in the pituitary and hypothalamus, triggering growth hormone (GH) release without significantly affecting cortisol or prolactin levels. This selectivity makes it a widely studied compound in endocrine, metabolic, and recovery research models.

Supplied as a 5mg lyophilized vial, Ipamorelin is intended for controlled laboratory research only.

Mechanism of Action

Ipamorelin mimics the action of ghrelin, binding to GHSR-1a receptors and activating intracellular signaling pathways that lead to GH release from the anterior pituitary. Unlike earlier GHS peptides such as GHRP-6, Ipamorelin exhibits minimal stimulation of ACTH and cortisol secretion, making it a “cleaner” GH secretagogue in research settings.

By stimulating endogenous GH, Ipamorelin indirectly increases circulating IGF-1, a key mediator of anabolic and regenerative processes.

Research Applications

• Growth hormone release and endocrine regulation studies
• Muscle recovery and repair models
• Bone density and connective tissue research
• Metabolic and fat utilization pathways
• Comparison to other GH secretagogues

In experimental setups, Ipamorelin is often paired with GHRH analogs (e.g., CJC-1295) to evaluate synergistic effects on GH secretion profiles.

Chemical Profile

Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH₂
Molecular Formula: C38H49N9O5
Molecular Weight: ~711.86 g/mol

Ipamorelin’s pentapeptide structure includes unnatural amino acids to increase stability and receptor selectivity. It is typically dissolved in bacteriostatic water for experimental use after reconstitution.

Comparison with Other Secretagogues

Compared to GHRP-2 and GHRP-6, Ipamorelin offers greater receptor selectivity, reduced side-effect profiles, and a smoother GH release curve. This makes it useful for studies requiring controlled GH elevation without significant off-target hormonal effects.

Storage & Stability

Store lyophilized Ipamorelin at −20°C, protected from light and moisture. After reconstitution, refrigerate at 2–8°C and use within protocol guidelines. Avoid repeated freeze–thaw cycles. Maintain aseptic handling.

For Research Use Only

Ipamorelin 5mg is intended strictly for laboratory research by qualified professionals. Not for human or veterinary use. Compliance with applicable regulations is required.

• Ipamorelin – Wikipedia
• Ghrelin – Wikipedia
• GHSR-1a Receptor – Wikipedia
• IGF-1 – Wikipedia