What is Fragment 176-191?

Fragment 176-191 is a synthetic peptide corresponding to a modified portion of the human growth hormone (hGH) amino acid chain. Specifically, it is derived from the C-terminal region, consisting of amino acids 176–191 of the full hGH molecule.

In research models, this fragment has been studied for its potential role in regulating lipid metabolism without the growth-promoting effects associated with intact hGH.

Mechanism of Action

Fragment 176-191 interacts with fat metabolism pathways by mimicking hGH’s ability to influence adipose tissue activity. It is believed to promote lipolysis (fat breakdown) and inhibit lipogenesis in research settings.

This selectivity makes it an appealing research target for exploring energy balance and weight regulation mechanisms.

Research Applications

• Fat metabolism and energy regulation studies
• Adipose tissue activity research
• Weight regulation models
• Comparative analysis with full hGH
• Metabolic pathway investigation

Researchers often use Fragment 176-191 to investigate the metabolic effects of isolated hGH segments versus the complete hormone.

Chemical Profile

Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Gly-Ser-Cys-Gly-Phe
Molecular Formula: C78H123N23O23S2
Molecular Weight: ~1817.12 g/mol

The sequence retains the metabolic regulatory regions of hGH while removing growth-stimulating domains.

Comparison to hGH

While full hGH exerts both anabolic and metabolic effects, Fragment 176-191 focuses primarily on lipid metabolism, making it valuable for targeted metabolic studies.

Storage & Stability

Store lyophilized Fragment 176-191 at −20°C, protected from light and moisture. After reconstitution, refrigerate at 2–8°C and use within research protocol timelines. Avoid repeated freeze–thaw cycles.

For Research Use Only

Fragment 176-191 5mg is intended strictly for laboratory research by qualified professionals. Not for human or veterinary use. All handling must comply with applicable regulations.

• Growth Hormone – Wikipedia
• Lipid Metabolism – Wikipedia
• Lipolysis – Wikipedia
• Adipose Tissue – Wikipedia