Introduction to AICAR

AICAR, short for 5-Aminoimidazole-4-carboxamide ribonucleotide, is a synthetic analog of adenosine monophosphate (AMP). In research, it is recognized for its ability to activate AMP-activated protein kinase (AMPK), a central regulator of cellular energy balance.

This 100mg preparation is designed for controlled laboratory experimentation, offering researchers a consistent and high-purity form of the compound.

Research Significance

AMPK activation by AICAR has been extensively studied for its role in mimicking the effects of exercise at a molecular level. In preclinical models, this activation influences glucose uptake, fatty acid oxidation, and mitochondrial biogenesis, making AICAR a compound of interest in metabolic and endurance research.

Studies also explore its potential relevance to cardiovascular health and adaptation to energy stress.

Mechanism of Action

AICAR enters cells and is converted to ZMP (AICA ribotide), which acts as an AMP analog. This promotes AMPK activation without requiring significant changes in the AMP:ATP ratio. Once active, AMPK shifts cellular metabolism toward energy production and conservation, downregulating processes that consume ATP.

These pathways are of particular interest in metabolic disease research, endurance performance modeling, and mitochondrial function studies.

Potential Study Areas

• Metabolic syndrome and insulin sensitivity
• Exercise mimetics and endurance adaptation
• Cardiovascular stress and protection models
• Mitochondrial biogenesis
• Energy metabolism regulation

Chemical Properties

Chemical Name: 5-Aminoimidazole-4-carboxamide ribonucleotide
Molecular Formula: C9H15N4O8P
Molecular Weight: ~338.21 g/mol
Form: Lyophilized powder

Supplied in a stable lyophilized form to preserve potency during storage and shipment.

Storage & Handling

Store lyophilized AICAR at −20°C in a light-protected environment. After reconstitution, keep refrigerated at 2–8°C and use within recommended research timelines. Avoid multiple freeze–thaw cycles.

For Research Use Only

AICAR 100mg is intended solely for laboratory-based research conducted by qualified professionals. Not for human or veterinary use.

• AICAR – Wikipedia
• AMPK – Wikipedia
• Mitochondria – Wikipedia