What is Follistatin 344?

Follistatin 344 is a synthetic peptide sequence based on the naturally occurring follistatin protein, a glycoprotein that binds and inhibits members of the TGF-β superfamily such as myostatin and activin.

By preventing these proteins from signaling, follistatin has been studied for its role in promoting muscle mass and supporting tissue repair in laboratory models.

Mechanism of Action

Follistatin 344 works by binding to myostatin and other ligands, neutralizing their inhibitory effect on muscle cell growth. This can result in enhanced muscle hypertrophy in research conditions.

It may also influence other growth factors, making it a versatile tool for studies involving regenerative medicine and musculoskeletal biology.

Research Applications

• Myostatin inhibition studies
• Muscle hypertrophy and repair research
• Bone density and tendon healing models
• Comparative analysis with other growth factors
• Regenerative medicine investigations

Follistatin 344 is often evaluated alongside IGF-1 and growth hormone in muscle and tissue regeneration studies.

Chemical Profile

Sequence: 344-amino-acid fragment of follistatin protein
Molecular Formula: C_xxH_xxN_xxO_xxS_x (varies by modification)
Form: Lyophilized peptide powder

This synthetic fragment is designed to retain the myostatin-binding domain of native follistatin.

Comparison to Other Follistatin Variants

Follistatin 344 is the most studied fragment due to its stability and bioactivity in research settings. Other forms, like Follistatin 315, differ in amino acid length and may show altered activity profiles.

Storage & Stability

Store lyophilized Follistatin 344 at −20°C, away from light and moisture. After reconstitution, refrigerate at 2–8°C and use within research protocol timelines. Avoid repeated freeze–thaw cycles.

For Research Use Only

Follistatin 344 1mg is intended strictly for laboratory research by qualified professionals. Not for human or veterinary use. All handling must comply with applicable regulations.

• Follistatin – Wikipedia
• Myostatin – Wikipedia
• Myogenesis – Wikipedia
• Muscle Hypertrophy – Wikipedia