What is CJC-1295 NO DAC (Mod GRF 1-29)?

CJC-1295 NO DAC, also known as Mod GRF 1-29, is a synthetic analog of growth hormone-releasing hormone (GHRH) designed without the DAC (Drug Affinity Complex) modification. This structure allows for shorter half-life activity, more closely mimicking natural pulsatile hormone release in research settings.

Mod GRF 1-29 has been studied in combination with other peptides to explore its effects on pituitary signaling and endocrine function.

Mechanism of Action

Like endogenous GHRH, CJC-1295 NO DAC binds to receptors in the anterior pituitary gland, stimulating the release of growth hormone. Its lack of DAC attachment results in a shorter duration of activity, making it ideal for studies on natural pulsatile secretion patterns.

This property differentiates it from CJC-1295 with DAC, which extends half-life but alters the release pattern.

Research Applications

• Growth hormone secretion studies
• Endocrine system regulation research
• Pituitary gland function models
• Comparative analysis with DAC-modified peptides
• Synergistic studies with GHRPs

In research models, Mod GRF 1-29 is frequently evaluated alongside GHRPs to assess combined effects on hormone signaling.

Chemical Profile

Sequence: Modified GHRH 1-29 sequence
Molecular Formula: C152H252N44O42
Molecular Weight: ~3367.93 g/mol

The peptide contains substitutions that increase stability compared to unmodified GHRH, while omitting the DAC modification for a shorter active window.

Comparison: NO DAC vs DAC

CJC-1295 with DAC prolongs half-life to several days, whereas NO DAC mimics the body’s natural growth hormone rhythm. This distinction makes NO DAC a preferred research tool when studying short-duration peptide signaling.

Storage & Stability

Store lyophilized CJC-1295 NO DAC at −20°C, away from light and moisture. After reconstitution, refrigerate at 2–8°C and use within research protocol timelines. Avoid repeated freeze–thaw cycles.

For Research Use Only

CJC-1295 NO DAC (Mod GRF 1-29) 5mg is intended strictly for laboratory research by qualified professionals. Not for human or veterinary use. All handling must comply with applicable regulations.

• GHRH – Wikipedia
• Pituitary Gland – Wikipedia
• Growth Hormone – Wikipedia