What is Matrixyl?

Matrixyl is the trade name for Palmitoyl Pentapeptide-4, a synthetic peptide designed for research in skin regeneration and wrinkle reduction. It is a fatty acid–linked pentapeptide, meaning a palmitic acid chain is attached to enhance skin penetration in topical delivery studies. Matrixyl has been investigated for its role in stimulating collagen and fibronectin production, key components of the skin’s extracellular matrix (ECM).

Supplied here in a 10mg lyophilized vial, Matrixyl is intended exclusively for controlled laboratory use.

Mechanism of Action

Matrixyl’s peptide sequence mimics a fragment of type I collagen, acting as a “messenger peptide” to signal fibroblasts to produce more structural proteins. In experimental settings, this can help counteract ECM degradation associated with aging and environmental stress.

By attaching a palmitic acid chain, the molecule becomes more lipophilic, which in topical models may enhance epidermal penetration and delivery to dermal fibroblasts.

Research Applications

• Skin aging and wrinkle depth studies
• Collagen and elastin synthesis stimulation
• Dermal remodeling and repair mechanisms
• ECM maintenance in photoaging models
• Comparison with other cosmetic peptides like Argireline and SNAP-8

In cell culture and ex vivo skin models, Matrixyl has been linked to increased expression of collagen types I, III, and IV, along with other ECM proteins.

Chemical Profile

Sequence: Palmitoyl-Lys-Thr-Thr-Lys-Ser
Molecular Formula: C39H75N7O10
Molecular Weight: ~802.07 g/mol

Matrixyl is typically supplied in lyophilized form for stability, with reconstitution performed using sterile, research-grade diluents before experimental application.

Comparison with Other Peptides

Matrixyl differs from neuropeptides like Argireline and SNAP-8, which focus on expression line reduction through neuromodulation. Instead, Matrixyl emphasizes structural support by targeting dermal matrix production. This makes it a common inclusion in anti-aging research formulations alongside hyaluronic acid and antioxidants for a multi-pronged approach to skin rejuvenation.

Storage & Stability

Store lyophilized vials at −20°C, protected from light and moisture. After reconstitution, refrigerate at 2–8°C and avoid repeated freeze–thaw cycles. Maintain aseptic handling and document storage conditions for reproducibility.

For Research Use Only

Matrixyl (Palmitoyl Pentapeptide-4) 10mg is intended strictly for laboratory research by qualified professionals. Not for human or veterinary use.

• Collagen – Wikipedia
• Fibronectin – Wikipedia
• Palmitic Acid – Wikipedia