What is Mod GRF 1-29 (CJC-1295 NO DAC)?

Mod GRF 1-29—often called CJC-1295 without DAC—is a stabilized analog of the first 29 amino acids of endogenous growth hormone-releasing hormone (GHRH). It retains the biologic activity of native GHRH(1-29) while incorporating substitutions to enhance stability against enzymatic breakdown.

Unlike CJC-1295 with DAC (Drug Affinity Complex), which is engineered for prolonged systemic exposure via albumin binding (source), the NO-DAC version is used in research to model pulsatile GHRH signaling.

Mechanism of Action

Mod GRF 1-29 binds GHRH receptors in the anterior pituitary gland, triggering physiologic growth hormone (GH) release. Downstream, GH stimulates hepatic and tissue production of IGF-1, a mediator of growth, repair, and metabolism. Because NO-DAC exhibits a shorter activity window than DAC, researchers use it to examine GH release patterns that more closely resemble natural pulses.

Why “NO DAC” Matters

• Pulsatile profile: Supports studies on circadian GH rhythm and sleep-linked secretion.
• Protocol flexibility: Easier to pair with timing-based designs (e.g., pre-sleep or post-training models).
• Comparative research: Contrast with DAC to differentiate sustained vs. transient exposure effects.

For background on the DAC variant, see CJC-1295 (Wikipedia).

Key Research Applications

• Growth hormone/IGF-1 axis physiology
• Metabolic regulation and body composition models
• Recovery, sleep quality, and circadian hormone dynamics
• Comparisons with Sermorelin and DAC-based CJC-1295
• Combination studies with GHS peptides (e.g., ipamorelin) for synergistic signaling

Chemical & Handling Notes

Form: 2mg lyophilized powder for reconstitution
Intent: Laboratory research by qualified personnel only

Storage (dry): −20°C, protected from light and moisture
After reconstitution: 2–8°C; avoid repeated freeze–thaw cycles

Document solvent, pH, and carrier proteins for reproducibility; time-of-sampling is critical when mapping pulsatile endpoints.

Comparison Snapshot

• Mod GRF 1-29 (NO DAC): shorter activity window; suited for pulse-driven designs.
• CJC-1295 with DAC: albumin-binding design for prolonged exposure (multi-day); suited for sustained-level studies. Learn more.

For Research Use Only

Mod GRF 1-29 (CJC-1295 NO DAC) 2mg is intended exclusively for laboratory research. Not for human or veterinary use. Follow all applicable regulations and institutional policies.

• CJC-1295 – Wikipedia
• GHRH – Wikipedia
• Pituitary Gland – Wikipedia
• IGF-1 – Wikipedia